Kinetic resolution of 2,3-epoxy 3-aryl ketones via catalytic asymmetric ring-opening with pyrazole derivatives.
نویسندگان
چکیده
A highly efficient catalytic kinetic resolution of 2,3-epoxy 3-aryl ketones via asymmetric ring-opening with pyrazole derivatives has been achieved by using a chiral N,N'-dioxide-Sc(III) complex as the catalyst. A wide variety of substrates were readily scoped, and the selectivity factors obtained were excellent (up to >300).
منابع مشابه
Synthesis of methyl 6-amino-5-cyano-4-aryl-2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylates using nanocrystalline ZnZr4(PO4)6 ceramics as an efficient catalyst
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عنوان ژورنال:
- Chemical communications
دوره 51 57 شماره
صفحات -
تاریخ انتشار 2015